Fred Greenwood Messages
Write To Karl Loren About This Page
Dear Karl,
Your level of understanding amazes me .. you have grasped it!!
I am going to write you some more detailed comments/info, but to get you started with this:
Chelation is normally thought of as removing metals .. in fact chelation never removes metal .. it only removes metal ions and since metal ions have such a high affinity for their unpaired electrons they will grab onto a cation .. so you end up removing the entire complex (metal ion plus its attached cation).
In the case we are talking about, the metal ion is zinc which is missing two electrons and it is attached to the protein forming an active MMP ... active due to the missing electrons and its potential for damage. Unlike regular proteins MMPs are enzymes .. which gives them immense power .. the power to control all extracellular matrix (ECM) functions including growth, form, size, etc.
So, if cancer starts and you have active MMP's, they will make the cancer grow and metastasize.
SO A VERY KEY POINT IS THAT CHELATION REMOVES THE ENTIRE ACTIVE MMP AND NOT JUST THE METAL ION.
SINCE ALL MMP'S ARE BASED ON THE METAL ZINC, IT DOESN'T ACCOMPLISH ANY THING TO DISCUSS OTHER METALS OTHER THAN TO SAY TAKE A MINERAL SUPPLEMENT TO REPLACE THEM.
If you were to test urine after chelation you would find a higher proportion of MMP's since they have been removed along with the zinc.
You could care less that the zinc has been removed .. you only care that MMP's have been removed.
The new concept is to get off the metal kick on chelation as it leads you nowhere.
In order to show that chelation benefits health you have to talk about the removal of MMP's by chelation.
Once you can show this, then the Biochemists will understand and you have linked chelation to the rest of the world.
Right now chelation is sitting as an orphan child for only the believers,
Others may know what chelation is, but could never figure out why it would improve health .. and therefore was quackery.
Nothing is quackery if based on science. Science has proven MMP's are the major health problem and that they are removed by chelation .. so we need to tell everyone.
Unfortunately, it is the chelation people who have held back chelation, by sticking to old theories and not looking at the science which has exploded in recent years. Tell me if the scientific world knows that chelation removes MMP's and they are spending big$$ trying to duplicate EDTA .. then why don't the chelation people know about MMP's .. because they don't follow science .. they just know it works and don't really care why .. but if asked will gin up an answer on why it works because they are supposed to know!!
I strongly encourage you to purchase the book "Oxidology" by Dr. Robert Bradford.
Go to www.americanbiologics.com and their will be an 800 number to call to order the book.
Dr. Bradford used to teach at Stanford (engineering). He left to open a Hospital in Mexico using Laetrile, chelation and other ways to treat cancer. He now teaches at Capitol University in Wash. D.C. He teaches all about free radicals (most consider him the world expert in oxidology .. the role of reactive oxygen species (ROS) in the body.
He invented the worlds most powerful light microscope .. up to 20,000x.
You can see red blood cells, Candida, bacteria, asbestos, etc in the live blood.
That is a drop of blood with all its living moving cells (basic life) can be seen with the Bradford microscope.
He has sold hundreds to communist China for the first time they can "see" why and how their herbs work.
They put Dr. Bradford on their Chinese Medical Board, and he is the only non-Chinese on that Board, now or ever!!
Anyhow get his book.
For better understanding, it would be good to briefly talk about extracellular matrix ECM).
ECM is the matrix outside the cells.
In a matrix of blood (a blood drop) you have primarily red blood cells sitting in a protein matrix called ECM.
(With the Bradford scope you can see the red blood cells and the ECM). The ECM contains SOD (sulfur oxide dismutase). SOD is a powerful anti-oxidant and contains copper and zinc. It is written as Cu-Zn SOD. SOD's are enzymes and they are MMP's. and are subject to damage by free radicals. Free radical damage activates MMP's, so does stress, surgery, blood flow changes, blood pressure.
More later ..
Best regards
Fred
Dear Karl,
As a follow-up on my last mail enclosing research which shows the relationship between free radicals (ROS) and MMP's.
Free radicals are one of the ways MMP's can be activated.
So free radicals can start a chain reaction.
All your work on free radicals is still valid, including the use of anti-oxidants.
Chelation removes the harmful MMP's and is therefore the real benefit.
MMP's can be activated without free radicals, though, so by removing bad MMP's you are dealing with all the results of extracellular matrix (ECM) degradation.
The analogy would be your liver as the garbage can of your body filtering out all the toxins, regardless of source.
Chelation like the liver (by analogy, only) removes all the toxic MMP's which are involved in all human health conditions. I sent you an article recently which showed that cancer patients have a higher percentage of MMP's in their urine .. and in the case of breast cancer it could be used as a predictor of disease with 96% certainty .. other cancers around 80%.
From this you can see the important role of MMP's.
Don't forget that MMP's are not just proteins, they are enzymes that control the body including disease progression. I think a good test for oral chelation would be to have urine MMP's measured before chelation (or 1 day after taking last dose) and again say 2 hours after a dose.
If the chelation is working there should be more MMP's 2 hours after a dose.
They are working on a standard urine test for cancer using MMP's in the urine.
Below is the article talking about ROS and relationship to MMP's.
Don't get discouraged as you have already come a long way in a short time and this stuff is all very new .. and for the first time we are relating chelation to all diseases.
nobody has ever done this.
I really encourage you to get the book, Oxidology, since where you are at I think it will really help. I have known Dr Bradford for 8 years and he is my hero .. like you I started with Durk's book and then didn't progress too far until I met Dr Bradford and later purchased his book. His book is sold mostly to Doctor's who have an interest in real biochemistry.
The attachment that came with this message is now located HERE.
Fred
Dear Karl,
The main reason I wanted you to get Bradford's book is that it is a very good primer for the background info leading to understanding MMP's/chelation, also he has some good definitions, it explains the role of "free radicals" or ROTS in degradation of the extracellular matrix (ECM).
The ECM which is protein, contains SOD, Sulfur Oxide Dismutase which is a copper-zinc (Cu-ZN) enzyme.
SOD is where the zinc comes from since SOD contains MMP's.
MMP's are not bad, they are good, only when they are ionic do they become "bad".
When the ECM is exposed to excessive oxidants (free radicals and compounds containing oxygen), then the SOD is degraded.
The ECM is degraded because SOD is part of the ECM.
Research has shown that supplements of SOD (American Biologics sells SOD) reverse ECM and SOD degradation, that is SOD itself is an anti-oxidant.
SOD is a CU-ZN which relies on a particular ratio of copper to zinc; if that ratio is upset in the direction of too much zinc (compared to copper), then you have ionic or bad MMP's.
Why because the zinc content of SOD is the same zinc used by MMP's. Even though, SOD contains zinc, it is of little importance because MMP's are based on zinc, not copper.
The only importance of copper is that a metabolic deficiency would lead to ionic MMP's due to an excess of zinc compared to copper.
Hair analysis would be the best way to ascertain proper copper/zinc ratio.
You can see why copper bracelets help some people with arthritis, the copper is leached out of the bracelet by skin acids (perspiration) and brings the Cu/Zn ratio of SOD back into balance.
With chelation, the same thing is accomplished as with the copper bracelet, except you are chelating the zinc containing MMP's to remove zinc as an EDTA-MMP complex T and bring the Cu/Zn ratio of SOD back into balance.
The ratio of copper to zinc can therefore be corrected by either adding copper or removing zinc, in this example.
Fred
Dear Karl,
I have not personally researched the role of chelation as far as its potential for removing "plaque" and if it does by what mechanism (research has shown that calcium containing plaque is almost always associated with nano bacteria .. extremely small bacteria only seen with an electron microscope.
Research has also shown that calcium build-ups around the body wherever it occurs is due to nanobacteria.
Just to say chelation removes metals and calcium is a metal is voodoo science, This talk about chelation removing this metal first and then that one is also based on poor science .. why? .. because metals are not sitting around unattached, so you have to consider the chemical nature of the compound the metal is involved with and not just the metal.
If the only part of the metal compound which is ionic is the metal part (i.e. zinc in the case of active MMP's), then and only then does the chelatability of the metal control what happens, first.
For the vast majority of people, chelation will remove more zinc than anything else, because it is in an ionic state as part of an MMP.
In other words, the most common toxin, is not calcium, lead, mercury, etc that chelation removes, it is active MMP's.
It is these same active MMP's that cause ECM related diseases (inflammation, growth and spreading of cancer, arthritis, skin wrinkles, warts, bone spurs, Alzheimer's, diabetes, neuropathy, etc).
Inflammation is of particular interest, because there is inflammation involved with all ECM diseases. In some cases inflammation is the disease itself (neuropathy, arthritis).
In other cases, inflammation is an initial step in the progression of the disease but not the most fatal part (Alzheimer's).
Inflammation is caused by cytokines which are part of the immune system (i.e. Tumor Necrosis Factor is the cytokine playing the biggest role in rheumatoid arthritis).
It is the ionic MMP's which allow the tissue to expand (swelling-which results in pain).
I personally witnessed the removal of swelling through chelation therapy given a rattle snake bite patient.
Cancer cells and other body cells have been found to have an abundance of MMP's attached to their cell surface.
When MMP inhibitors (chelation is an MMP inhibitor, albeit a non-selective one since it removes all bad MMP's) are given to cancer patients, it has been shown that their tumors shrink.
Other MMP inhibitors have been shown to affect the adhesion of the cancerous cells to other cells and tissue,
All of this is still evolving with new research every day.
Several MMP inhibitors for cancer are in the final stages of clinical trials,
Within a year or two the medical establishment will have a pill which will basically do the same thing as chelation.
At least NIH is finally doing clinical trials on chelation, about 2,300 people and a 5 year study. I wish they were going to measure zinc and MMP content of urine, before and throughout the trial period .. but they do not know about MMP's and chelation. I have found numerous references where urine has been tested and in all cases the primary metal removed is zinc.
There is one really good reference, which I think you already have which shows that MMP content is a good diagnostic test for cancer, particularly hormonal cancers (breast, prostrate), but in general all cancers.
They feel this test would be much better than a mammogram which is about 50%(at best) accurate, whereas a MMP urine test predicts breast cancer 96% of the time!!
Fred
Dear Karl
I hope you can appreciate the situation. it is difficult for you to fully understand now as you have not yet fully understood the role of MMP's in the body and how they are affected by chelation.
Once you understand, everything will fall into place including what to do with your existing writings. I would encourage you to read a little more in Bradford's book.
The main thing for you to get out of that is regarding the subject of SOD and degradation of SOD by oxidants.
This is the most basic background info to understanding MMP's, importance of zinc and therefore chelation.
Whenever you want to check your progress, just go to the E-Mail submittal that talked about DOTS and see if you understand and accept all the statements represented by each DOT.
You wont be able to do this unless you read and understand the Medline research which supports these DOTS. So use these Medline research articles to help tell you what you don't understand, and then feel free to ask me.
I feel you are well aware that chelation removes zinc before talking to me, but I don't think you still understand that zinc is the primary metal removed as a MMP/zinc/EDTA complex.
So look at the articles which support DOT 1.
(I have found numerous other ones since, I will send you at least one. This is a crucial point. Until you can read evidence showing chelation results in zinc (and MMP's) in urine with a higher zinc removal than other metals, you will be stuck with the old theories.
Also why do cancer patients have MMP's in their urine? Everyone eats sufficient EDTA to remove some MMP's and the urine content will be dependent on both the amount of EDTA absorbed and the concentration of MMP's in the body. Since cancer cells have MMP's attached to their surface, cancer patients secrete a large number of MMP's.
If urine MMP content predicts cancer in a patient, isn't it reasonable that anything that could lower urine MMP means the patient is getting better? What I am suggesting, Karl, is that nobody has to understand the science behind MMP's etc since urine tests tell the whole story. If it can be shown that chelation removes zinc, that the zinc removed is really not the metal itself but MMP's (MMP's contain zinc, but if you measure zinc in urine, you will not know it was part of the MMP's-you would also have to measure MMP's in urine), and that MMP level predicts cancer status, then that's all we need ... you can forget the science! The problem with science is that it is hard to understand and people will also argue over what the science means.
So, I think we should step back and put the science aside and concentrate on results of tests, as those are easier to understand, more direct proof than science and easier to defend.
Fred
Dear Karl,
Re your question as to whether an active MMP is a free radical.
Although, it may seem like a free radical because it contains cationic zinc ions, it technically is not a free radical (and I realize I previously said it was free radical), It really is worse or more harmful than a free radical. MMP's have something called a "cysteine switch" built into their DNA. When this switch is activated or opened, then and only then do you have an active MMP which plays a harmful role in cancer progression. The attached article describes this very well and is a key article for you to use/reference.
I had sent it previously.
P.S. Even though this cysteine switch is a little complicated, I feel it is worth some attention as it is a key point.
The way I look at is once the MMP switch is activated, the MMP is programmed to do bad things (cancer growth etc). Fortunately, active MMP's can be chelated due to the zinc cations (you could say that the active MMP acts like a free radical in this sense), but it is more (and worse) than a free radical because it is programmed by DNA to do harm, whereas a free radical is not DNA programmed.
One way to explain it would be to say that an active MMP is a programmed free radical.....see what you think after reading the attachment.
I FEEL THIS POINT YOU HAVE ASKED ABOUT IS VERY IMPORTANT.
Fred
I particularly like the part about the need for orthodox and alternative medical people to agree on the causes of medical conditions. Attached (with Karl Loren inserted comments)
Fred
Dear Karl,
I agree with the comments you inserted in the just above article
Fred
Dear Karl,
Here is a good article talking about the active MMP cascade which I call a chain reaction. It also explains why a drug which inhibits only certain active MMP's would be ineffective (there are too many different types of active MMP's in the latter stages of disease progression). Fortunately chelation inhibits all active MMP's and removes them from the body.
Fred
Attached, published HERE as: MATRIX METALLOPROTEINASES (MMPS)
Dear Karl,
How does this sound?:
An active MMP is similar to a free radical in that it contains zinc cations, but, unlike free radicals, active MMP's are programmed by DNA to do wholesale chain-reaction like harm to health. One might call Active MMP's the body's weapons of mass destruction. They degrade all cells and the extracellular matrix resulting in inflammation , tissue change (remodeling), and disease progression (including cancer tumor growth and metastasis, or spreading). As, disease progresses, active MMP's promulgate more MMP's both in number and type, multiplying their damaging affect many times over. Fortunately, the active MMP zinc cations allow them to be chelated and removed through the kidneys. In this manner, it can be argued that chelation is the best alternative medical treatment to control and in some cases reverse disease progression; particularly as a supplement to orthodox therapies (i.e. chemotherapy and radiation). Your prose is better than mine, but I thought it might be helpful at this important point to give you a running start.
Fred
Dear Karl,
I have a number of things that I have been working on which I can send you .. iust let me know if there is any order of priority for doing so. These items are:
1. Information which supports your oral chelation formula relative to removal of MMP's.
2.Information showing that EDTA has been used in Biochemical Research at Drug Companies and Universities, for at least 12 years, as the standard method of identification of active MMP's.
3.Information which would allow you, through, a new product, to get 100% adsorption of EDTA in doses comparable to IV.
4.Numerous urine test results showing that chelation works by chelating active MMP's.
5.Information supporting the developmnt of other new products based on MMP's. If you want any information relative to items 3 or 5, we should first establish a business relationship.
P.S. I read and enjoyed your Wednesday newsletter and it was great toget it pre-publication.
Fred
October 30, 2002
Dear Karl
We both share an introduction to the science of biochemistry (as it relates to human health) in the reading of Durk Pearson's book, LifeExtension.
Durk was the first one to take the biochemistry of health and present it to the public in an understandable fashion.
All of the statements/conclusions in his book of any consequence were supported by published scientific research (as referenced in his book) or Durk's own research, including he and Sandy's use of supplements.
In his book, Durk cautions readers not to rely on anything that is written without referenced/supporting scientific evidence.
The fact that this book was a best seller 10 years ago and has stood the test of time (except for not being up-to-date) is a tribute to Durk's approach in writing this book.
It was also written so that it could be used as a reference by M.D."s. I call Durk's approach to writing his book "the scientific approach".
Science is the basis of all true human understanding of this God-given world. Science brings order out of chaos and the scientific approach to writing communicates information in the most truthful orderly and noncontroversial manner. It allows all readers whether they be scientists, doctors or the general public to communicate, review and understand on a common basis.
Contrary to this approach would be writing based on opinion, myths and /or scientifically unsupported statements and conclusions. (it is this approach which has plagued the chelation industry and much of alternative medicine).
I believe in the former approach and want nothing to do with the latter approach.
Everything I have submitted to you has been supported by scientific research and as such it does not represent my opinions or my theory.
My contribution has been to do what nobody else has done in the Chelation Industry; and that is to seek out the scientific basis for why chelation works and the resulting true benefit which far exceeds commonly accepted understanding.
A new medical discipline called Integrative Medicine has emerged and is now being taught in many medical schools. Integrative Medicine combines the science of orthodox medicine with the science of so-called alternative medicine.
This is the approach to medicine to which I subscribe. At first I thought you were going to write about the science of chelation and integrate that science with the science of orthodox medicine.
Rather, what I see happening is writing that contains a soup of science mixed with scientifically unsupported alternative approaches and philosophys.
This is fine, because it is your web-site not mine, but I do not want my name associated with these writings.
You may, if you please, keep my name associated with the information I have written and submitted to you. As Durk's book proved, there is a great need to publish the truth about health and medicine.
I was hoping I could be part of such an effort.
Your continued referral to bad relationships as the sole cause of major illnesses is mystifying.
Bad relationships can and do create stress on the mind and body which have an affect on disease pathology, but they are not the sole factor.
I realize you are a philosopher; but philosophy has no place mixed in with the writing of science. I hope we can keep in touch and feel free to contact me at any time.
As of now I am removing myself from support of your writings.
I hope you understand my position; but do not expect you to agree with it.
Fred
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